Digitalis in the context of Phylogenetic

The Lamiales (also known as the mint order) are an order of flowering plants in the asterids clade of the Eudicots. Under the APG IV system of flowering plant classification the order consists of 24 families, and includes about 23,810 species and 1,059 genera with representatives found all over the world. Well-known or economically important members of this order include aromatic, culinary, and medicinal herbs such as basil, mint, rosemary, sage, savory, marjoram, oregano, hyssop, thyme, lavender, perilla, lemon verbena, catnip, bee balm, wild dagga, and oriental motherwort, as well as olives, ash trees, teak, foxgloves, lilacs, jasmine, snapdragons, African violets, Jacarandas, Paulownias, butterfly bushes, sesame, and psyllium.

Asterids are a large clade (monophyletic group) of flowering plants, composed of 17 orders and more than 80,000 species, about a third of the total flowering plant species. The asterids are divided into the unranked clades lamiids (8 orders) and campanulids (7 orders), and the single orders Cornales and Ericales. Well-known asterids include dogwoods and hydrangeas (order Cornales), tea, blueberries, cranberries, kiwifruit, Brazil nuts, argan, sapote, and azaleas (order Ericales), sunflowers, lettuce, common daisy, yacon, carrots, celery, parsley, parsnips, ginseng, ivies, holly, honeysuckle, elder, and valerian (clade campanulids), borage, forget-me-nots, comfrey, coffee, frangipani, gentian, pong-pong, oleander, periwinkle, basil, mint, rosemary, sage, oregano, thyme, lavender, wild dagga, olives, ash, teak, foxgloves, lilac, jasmine, snapdragons, African violets, butterfly bushes, sesame, psyllium, potatoes, eggplants, tomatoes, chilli peppers, tobacco, petunias, morning glory, and sweet potato (clade lamiids).

Most of the taxa belonging to this clade had been referred to as Asteridae in the Cronquist system (1981) and as Sympetalae in earlier systems. The name asterids (not necessarily capitalised) resembles the earlier botanical name but is intended to be the name of a clade rather than a formal ranked name, in the sense of the ICBN.

Plantaginaceae, the plantain family or veronica family, is a large, diverse family of flowering plants in the order Lamiales that includes common flowers such as snapdragon and foxglove. It is unrelated to the banana-like fruit also called "plantain". In older classifications, Plantaginaceae was the only family of the order Plantaginales, but numerous phylogenetic studies, summarized by the Angiosperm Phylogeny Group, have demonstrated that this taxon should be included within Lamiales.

Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as defensive poisons in several plant genera such as Digitalis (the foxgloves) and Asclepias (the milkweeds), these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment.

William Withering FRS (17 March 1741 – 6 October 1799) was an English botanist, geologist, chemist, physician and first systematic investigator of the bioactivity of digitalis.

Withering was born in Wellington, Shropshire, the son of a surgeon. He trained as a physician and studied medicine at the University of Edinburgh Medical School. He worked at Birmingham General Hospital from 1779. The story is that he noticed a person with dropsy (swelling from congestive heart failure) improve remarkably after taking a traditional herbal remedy; Withering became famous for recognising that the active ingredient in the mixture came from the foxglove plant. The active ingredient is now known as digoxin, after the plant's scientific name. In 1785, Withering published An Account of the Foxglove and some of its Medical Uses, which contained reports on clinical trials and notes on digitalis's effects and toxicity.