Demetrios Palaiologos or Demetrius Palaeologus (Greek: Δημήτριος Παλαιολόγος, romanized: Dēmētrios Palaiologos; 1407–1470) was Despot of the Morea together with his brother Thomas from 1449 until the fall of the despotate in 1460. Demetrios and Thomas were sons of Byzantine Emperor Manuel II Palaiologos, and brothers of the final two emperors John VIII and Constantine XI. Demetrios had a complicated relationship with his brothers, whom he frequently quarrelled with, usually over the matter of Demetrios's wish to establish himself as the most senior of them and claim the imperial throne for himself.
In 1437, Demetrios accompanied his elder brother John VIII to the Council of Florence, the main objective of which was to unify the Roman Catholic and Eastern Orthodox churches so that Western Europe might be more inclined to lend military aid to the desperate Byzantine Empire. Even though Demetrios was staunchly against a union of the churches, he was brought along as John did not dare to leave him in the east without he himself being present. Demetrios attempted to claim the throne twice, first attempting to take it with Ottoman support in 1442 and then by hoping to be proclaimed emperor after John VIII's death in 1448. Both attempts failed and in 1449, Demetrios was proclaimed as Despot of the Morea by the new emperor, his brother Constantine XI.