Count of Guise and Duke of Guise (/ɡwiːz/ GWEEZ, French: [ɡ(ɥ)iz]) were titles in the French nobility.
Originally a seigneurie, in 1417 Guise was erected into a county for René, a younger son of Louis II of Anjou.
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Count of Guise in the context of René II, Duke of Lorraine
René II (2 May 1451 – 10 December 1508) was Count of Vaudémont from 1470, Duke of Lorraine from 1473, and Duke of Bar from 1483 to 1508. He claimed the crown of the Kingdom of Naples and the County of Provence as the Duke of Calabria 1480–1493 and as King of Naples and Jerusalem 1493–1508. He succeeded his uncle John of Vaudémont as Count of Harcourt in 1473, exchanging it for the county of Aumale in 1495. He succeeded as Count of Guise in 1504.
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