Cosimo III de' Medici, Grand Duke of Tuscany in the context of "Medici"

Ferdinando de' Medici (9 August 1663 – 31 October 1713) was the eldest son of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans. Ferdinando was heir to the Grand Duchy of Tuscany, with the title Grand Prince, from his father's accession in 1670 until his death in 1713. He is remembered today primarily as a patron of music. An excellent musician himself (sometimes called "the Orpheus of princes"), he attracted top musicians to Florence and thus made it an important musical center. Through his patronage of Bartolomeo Cristofori, Ferdinando made possible the invention of the piano.

Anna Maria Luisa de' Medici (11 August 1667 – 18 February 1743) was an Italian noblewoman who was the last lineal descendant of the main branch of the House of Medici. A patron of the arts, she bequeathed the Medicis' large art collection, including the contents of the Uffizi, Palazzo Pitti, and the Medici villas, which she inherited upon her brother Gian Gastone's death in 1737, and her Palatine treasures to the Tuscan state, on the condition that no part of it could be removed from "the Capital of the grand ducal State....[and from] the succession of His Serene Grand Duke."

Anna Maria Luisa was the only daughter of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans, a niece of Louis XIII of France. On her marriage to Johann Wilhelm, Elector Palatine, she became Electress of the Palatinate, and, by patronising musicians, she earned for the contemporary Palatine court the reputation of an important music centre. As Johann Wilhelm had syphilis the union produced no offspring, which, combined with her siblings' barrenness, meant that the Medici were on the verge of extinction.

Francesco Redi (18 February 1626 – 1 March 1697) was an Italian physician, naturalist, biologist, and poet. He is referred to as the "founder of experimental biology", and as the "father of modern parasitology". He was the first person to challenge the theory of spontaneous generation by demonstrating that maggots come from eggs of flies.

Having a doctoral degree in both medicine and philosophy from the University of Pisa at the age of 21, he worked in various cities of Italy. A rationalist of his time, he was a critic of verifiable myths, such as spontaneous generation. His most famous experiments are described in his magnum opus Esperienze intorno alla generazione degl'insetti (Experiments on the Generation of Insects), published in 1668. He disproved that vipers drink wine and could break glasses and that their venom was poisonous when ingested. He correctly observed that snake venoms were produced from the fangs, not the gallbladder, as was believed. He was also the first to recognize and correctly describe details of about 180 parasites, including Fasciola hepatica and Ascaris lumbricoides. He also distinguished earthworms from helminths (like tapeworms, flukes, and roundworms). He possibly originated the use of the control, the basis of experimental design in modern biology. A collection of his poems first published in 1685 Bacco in Toscana (Bacchus in Tuscany) is considered among the finest works of 17th-century Italian poetry, and for which the Grand Duke Cosimo III gave him a medal of honour.

The Grand Duchy of Tuscany (Italian: Granducato di Toscana; Latin: Magnus Ducatus Etruriae) was an Italian monarchy located in Central Italy that existed, with interruptions, from 1569 to 1860, replacing the Republic of Florence. The grand duchy's capital was Florence. In the 19th century the population of the Grand Duchy was about 1,815,000 inhabitants.

Having brought nearly all Tuscany under his control after conquering the Republic of Siena, Cosimo I de' Medici, was elevated by a papal bull of Pope Pius V to Grand Duke of Tuscany on 27 August 1569. The Grand Duchy was ruled by the House of Medici until the extinction of its senior branch in 1737. While not as internationally renowned as the old republic, the grand duchy thrived under the Medici and it bore witness to unprecedented economic and military success under Cosimo I and his sons, until the reign of Ferdinando II, which saw the beginning of the state's long economic decline. That economic decline continued under Cosimo III.