Cooks Creek (Antigua) in the context of Saint Mary, Antigua and Barbuda

Saint Mary (South Antiguan Creole: Sen Mieree), officially the Parish of Saint Mary, is a parish of Antigua and Barbuda on the island of Antigua. Saint Mary borders Saint John to the north, and Saint Paul to the east. Saint Mary is dominated by the Shekerley Mountains, and its northern border is largely defined by the mountains, and by Cooks Creek. The largest city in the parish is Bolans, home to the Jolly Harbour neighbourhood, and the parish church is located in Old Road. Saint Mary was permanently established with the other four original parishes in 1692. It had an estimated population of 8,141 in 2018.

The only area in which the Antigua black pineapple can be produced is the Pineapple Belt, which includes Saint Mary. The settlements of Old Road and Urlings are located in the southern part of the parish, and Bolans and Jennings are located in the flat northern half of the parish, where the majority of Saint Mary's population is concentrated. The Shekerley Mountains shield most of the parish's land area from human population, leaving the remaining portion of the parish largely uninhabited. The remote community of John Hughes, which has less ties to the parish as a whole than to Swetes in Saint Paul, is one of the few settlements found inside the Sherkerley Mountains.