Contact immunity in the context of Attenuated vaccine


Contact immunity in the context of Attenuated vaccine

⭐ Core Definition: Contact immunity

Contact immunity is the property of some vaccines, where a vaccinated individual can confer immunity upon unimmunized individuals through contact with bodily fluids or excrement. In other words, if person "A" has been vaccinated for virus X and person "B" has not, person "B" can receive immunity to virus X just by coming into contact with person "A". The term was coined by Romanian physician Ioan Cantacuzino.

The potential for contact immunity exists primarily in "live" or attenuated vaccines. Vaccination with a live, but attenuated, virus can produce immunity to more dangerous forms of the virus. These attenuated viruses produce little or no illness in most people. However, the live virus multiplies briefly, may be shed in body fluids or excrement, and can be contracted by another person. If this contact produces immunity and carries no notable risk, it benefits an additional person, and further increases the immunity of the group.

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Contact immunity in the context of Poliomyelitis eradication

Polio eradication, the goal of permanent global cessation of circulation of the poliovirus and hence elimination of the poliomyelitis (polio) it causes, is the aim of a multinational public health effort begun in 1988, led by the World Health Organization (WHO), the United Nations Children's Fund (UNICEF) and the Rotary Foundation. These organizations, along with the U.S. Centers for Disease Control and Prevention (CDC) and The Gates Foundation, have spearheaded the campaign through the Global Polio Eradication Initiative (GPEI). Successful eradication of infectious diseases has been achieved twice before, with smallpox in humans and rinderpest in ruminants.

Prevention of disease spread is accomplished by vaccination. There are two kinds of polio vaccine—oral polio vaccine (OPV), which uses weakened poliovirus, and inactivated polio vaccine (IPV), which is injected. OPV is less expensive and easier to administer, and can spread immunity beyond the person vaccinated, creating contact immunity. It has been the predominant vaccine used. However, under conditions of long-term vaccine virus circulation in under-vaccinated populations, mutations can reactivate the virus to produce a polio-inducing strain, while OPV can also, in rare circumstances, induce polio or persistent asymptomatic infection in vaccinated individuals, particularly those who are immunodeficient. IPV, being inactivated, does not carry these risks, but does not induce contact immunity. IPV is more costly and the logistics of its delivery are more challenging.

View the full Wikipedia page for Poliomyelitis eradication
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