Colombian Massif in the context of Cordillera Occidental, Colombia

The Cordillera Oriental (English: Eastern Ranges) is the widest of the three branches of the Colombian Andes. The range extends from south to north, dividing from the Colombian Massif in Huila Department to Norte de Santander Department where it splits into the Serranía del Perijá and the Cordillera de Mérida in Venezuelan Andes. The highest peak is Ritacuba Blanco at 5,410 m (17,750 ft) in the Sierra Nevada del Cocuy.

The Andean region, located in central Colombia, is the most populated natural region of Colombia. With many mountains, the Andes contain most of the country's urban centers. They were also the location of the most significant pre-Columbian indigenous settlements as well as the region with the most European influence due to immigration from the colony to the present day. Beyond the Colombian Massif in the south-western departments of Cauca and Nariño, the Colombian Andes divide into three branches known as "cordilleras" (from the Spanish for mountain range): the West Andes run adjacent to the Pacific coast and is home to the city of Cali. The Central Andes run up the center of the country between the Cauca and Magdalena river valleys (to the west and east respectively) and includes the cities of Medellín, Manizales and Pereira. The East Andes extend northeast towards the Guajira Peninsula, and includes the cities of Bogotá, Bucaramanga and Cúcuta.

The climate and vegetation of the region vary considerably according to altitude, but as a general rule the land can be divided into the tierra caliente (hot land) of river valleys and basins below 1,000 m; the more temperate conditions of the tierra templada (temperate land, approximately 1,000 m to 2,000 m) and tierra fría (cold land, 2,000 m to 3,200 m), which include the most productive land and most of the population; and the alpine conditions of the zona forestada (forested zone, 3,200 m to 3,900 m), páramos (3,900 m to 4,600 m) and tierra helada (frozen land, 4,600 m and above).

The Cordillera Occidental (English: Western Ranges) is the lowest in elevation of the three branches of the Colombian Andes. The average altitude is 2,000 m (6,600 ft) and the highest peak is Cerro Tatamá at 4,100 m (13,500 ft). The range extends from south to north dividing from the Colombian Massif in Nariño Department, passes north through Cauca, Valle del Cauca, Risaralda, Chocó, and Caldas Departments to the Paramillo Massif in Antioquia and Córdoba Departments. The cordillera is paralleled on the east by the Cauca river. From this massif the range divides further to form the Serranías de Ayapel, San Jerónimo and Abibe. Only to recede into the Caribbean plain and the Sinú River valley.

It is a direct continuation of Cordillera Occidental of Ecuador.

The Cordillera Central (English: Central Ranges) is the highest of the three branches of the Colombian Andes. The range extends from south to north dividing from the Colombian Massif in Cauca Department to the Serranía de San Lucas in Bolivar Departments. The highest peak is Nevado del Huila at 5,364 m (17,598 ft).

Significant graphite resources exists in Cordillera Central in the form of graphite-bearing schists.