Cleopatra I in the context of "Ptolemy VIII Physcon"

Ptolemy VI Philometor (Greek: Πτολεμαῖος Φιλομήτωρ, Ptolemaĩos Philomḗtōr; 186–145 BC) was a Greek king of Ptolemaic Egypt who reigned from 180 to 164 BC and from 163 to 145 BC. He is often considered the last ruler of ancient Egypt when that state was still a major power.

Ptolemy VI, the eldest son of King Ptolemy V and Queen Cleopatra I, came to the throne aged six when his father died in 180 BC. The kingdom was governed by regents: his mother until her death in 178 or 177 BC and then two of her associates, Eulaeus and Lenaeus, until 169 BC. From 170 BC, his sister-wife Cleopatra II and his younger brother Ptolemy VIII were co-rulers alongside him. Ptolemy VI's reign was characterised by external conflict with the Seleucid Empire over Syria and by internal conflict with his younger brother for control of the Ptolemaic monarchy. In the Sixth Syrian War (170–168 BC), the Ptolemaic forces were utterly defeated and Egypt was twice invaded by Seleucid armies. A few years after the Seleucid conflict ended, Ptolemy VIII succeeded in expelling Ptolemy VI from Egypt in 164 BC.

Ptolemy VIII Euergetes II Tryphon (Greek: Πτολεμαῖος Εὐεργέτης Τρύφων, Ptolemaĩos Euergétēs Tryphōn, "Ptolemy the Benefactor, the Opulent"; c. 184 BC – 28 June 116 BC), nicknamed Physcon (Φύσκων, Physkōn, "Fatty"), was a king of the Ptolemaic kingdom . He was the younger son of King Ptolemy V and Queen Cleopatra I. His reign was characterised by fierce political and military conflict with his older siblings, Ptolemy VI and Cleopatra II.

Ptolemy VIII was originally made co-ruler with his siblings in the run-up to the Sixth Syrian War, in 170 BC. In the course of that war, Ptolemy VI was captured and Ptolemy VIII arguably became sole king of Egypt. When the war ended and Ptolemy VI was restored to the throne in 168 BC, the two brothers continued to quarrel. In 164 BC Ptolemy VIII drove out his brother and became sole king of the Ptolemaic empire, but he was expelled in turn in 163 BC. As a result of Roman intervention, Ptolemy VIII was awarded control of Cyrene. From there he repeatedly tried to capture Cyprus, which had also been promised to him by the Romans, from his brother.

Cleopatra Selene (Ancient Greek: Κλεοπάτρα Σελήνη; c. between 135 and 130 – 69 BC) was the Queen consort of Egypt (Cleopatra Selene or Cleopatra V Selene) from 115 to 102 BC, the Queen consort of Syria from 102 to 92 BC, and the monarch of Syria (Cleopatra II) from 82 to 69 BC. The daughter of Ptolemy VIII Physcon and Cleopatra III of Egypt, Cleopatra Selene was favoured by her mother and became a pawn in Cleopatra III's political manoeuvres. In 115 BC, Cleopatra III forced her son Ptolemy IX to divorce his sister-wife Cleopatra IV, and chose Cleopatra Selene as the new queen consort of Egypt. Tension between the king and his mother grew and ended with his expulsion from Egypt, leaving Cleopatra Selene behind; she probably then married the new king, her other brother Ptolemy X.

Following the marriage of the Syrian Seleucid princess Cleopatra I to Ptolemy V of Egypt, dynastic marriages between the two kingdoms became common. In 102 BC, Cleopatra III decided to establish an alliance with her nephew Antiochus VIII of Syria; Cleopatra Selene was sent as his bride. After his assassination in 96 BC, she married his brother and rival Antiochus IX. Cleopatra Selene lost her new husband in 95 BC and married a final time to Antiochus IX's son Antiochus X, who disappeared from the records and is presumed to have died in 92 BC, but may have remained in power until 89/88 BC (224 SE (Seleucid year)). Cleopatra Selene then hid somewhere in the kingdom with her children. Eventually, Syria split between the sons of Antiochus VIII with Philip I ruling in the Syrian capital Antioch and Antiochus XII in the southern city Damascus.