Chromosome rearrangement in the context of "Deletion (genetics)"

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⭐ Core Definition: Chromosome rearrangement

In genetics, a chromosomal rearrangement is a mutation that is a type of chromosome abnormality involving a change in the structure of the native chromosome. Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations. Usually, these events are caused by a breakage in the DNA double helices at two different locations, followed by a rejoining of the broken ends to produce a new chromosomal arrangement of genes, different from the gene order of the chromosomes before they were broken. Structural chromosomal abnormalities are estimated to occur in around 0.5% of newborn infants.

Some chromosomal regions are more prone to rearrangement than others and thus are the source of genetic diseases and cancer. This instability is usually due to the propensity of these regions to misalign during DNA repair, exacerbated by defects of the appearance of replication proteins (like FEN1 or Pol δ) that ubiquitously affect the integrity of the genome.Complex chromosomal rearrangements (CCR) are rarely seen in the general population and are defined as structural chromosomal rearrangements with at least three breakpoints with exchange of genetic material between two or more chromosomes. Some forms of campomelic dysplasia, for example, result from CCRs.

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Chromosome rearrangement in the context of Antheraea pernyi

Antheraea pernyi, the Chinese oak tussar moth, Chinese tasar moth, or temperate tussar moth, is a large moth in the family Saturniidae. The species was first described by Félix Édouard Guérin-Méneville in 1855. Antheraea roylei is an extremely close relative, and the present species might actually have evolved from ancestral A. roylei by chromosome rearrangement.

They are originally from southern China. Used for tussar silk production, they have been distributed more widely across subtropical and tropical Asia. Unlike the domestic silk moth which is entirely dependent on human care, tussah silk moths can survive in the wild if they escape from captivity; small local populations of such feral stock may thus occasionally occur. The colour and quality of the silk depends on the climate and soil.

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Chromosome rearrangement in the context of Chromosomal inversion

An inversion is a chromosome rearrangement in which a segment of a chromosome becomes inverted within its original position. An inversion occurs when a chromosome undergoes two breaks within the same chromosomal arm, and the segment between the two breaks inserts itself in the opposite direction in the same chromosome arm. The breakpoints of inversions often happen in regions of repetitive nucleotides, and the regions may be reused in other inversions. Chromosomal segments in inversions can be as small as 1 kilobase or as large as 100 megabases. The number of genes captured by an inversion can range from a handful of genes to hundreds of genes. Inversions can happen either through ectopic recombination between repetitive sequences, or through chromosomal breakage followed by non-homologous end joining.

Inversions are of two types: paracentric and pericentric. Paracentric inversions do not include the centromere, and both breakpoints occur in one arm of the chromosome. Pericentric inversions span the centromere, and there is a breakpoint in each arm.

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Chromosome rearrangement in the context of Antheraea roylei

Antheraea roylei is a large moth in the family Saturniidae occurring in Nepal, Thailand, Burma, Vietnam, West Malaysia, and the Himalayan regions of India, as well as Northern Pakistan. The species is considered to be the wild progenitor of the domesticated species known as Antheraea pernyi; the theory is that pernyi may have evolved from ancestral A. roylei by chromosome rearrangement during domestication.

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