Chloroformic acid in the context of "Peptide synthesis"

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⭐ Core Definition: Chloroformic acid

Chloroformic acid is a chemical compound with the formula ClCO2H. It is the single acyl-halide derivative of carbonic acid (phosgene is the double acyl-halide derivative). Chloroformic acid is also structurally related to formic acid, in a way that the non-acidic hydrogen of formic acid is replaced by chlorine. Despite the similar name, it is very different from chloroform. It is described as unstable, decomposing into carbon dioxide and hydrogen chloride.

Chloroformic acid itself is too unstable to be handled for chemical reactions. However, many esters of this carboxylic acid are stable and these chloroformates are important reagents in organic chemistry. They are used to prepare mixed carboxylic acid anhydrides used in peptide synthesis.Important chloroformate esters include 4-nitrophenyl chloroformate, fluorenylmethyloxycarbonylchloride, benzyl chloroformate and ethyl chloroformate.

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Chloroformic acid in the context of Organic compound

Organic compounds are a subclass of chemical compounds of carbon. Little consensus exists among chemists on the exact definition of organic compound; the only universally accepted definition is the quasi-tautological "organic compounds are the subject matter of organic chemistry".

Generally, any large chemical compound containing a carbon–hydrogen or carbon–carbon bond is accepted as an organic compound. Thus alkanes (e.g. ethane, CH3−CH3) and their derivatives are typically considered organic. For historical and disciplinary reasons, small molecules containing carbon are generally not accepted: cyanide ion (CN), hydrogen cyanide (HCN), chloroformic acid (ClCO2H), carbon dioxide (CO2), and carbonate ion (CO2−3) may all be excluded.

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LINKED FROM (PARENTS)
← Organic compound ← Organic compounds ← Synthetic compound ← Organic molecules ← Organic substance ← Organic molecule ← Organic chemical
LINKS TO (CHILDREN)
Chemical compound → Chlorine → Carbon → Oxygen → Hydrogen → Carbonic acid → Phosgene → Formic acid → Chloroform → Ester → Carboxylic acid → Chloroformate → Carboxylic acid anhydride → Peptide synthesis → Fluorenylmethyloxycarbonylchloride → Benzyl chloroformate → Ethyl chloroformate →