Cerro de las Mesas in the context of Veracruz City

The Epi-Olmec culture was a cultural area in the central region of the present-day Mexican state of Veracruz. Concentrated in the Papaloapan River basin, a culture that existed during the Late Formative period, from roughly 300 BCE to roughly 250 CE. Epi-Olmec was a successor culture to the Olmec, hence the prefix "epi-" or "post-". Although Epi-Olmec did not attain the far-reaching achievements of that earlier culture, it did realize, with its sophisticated calendrics and writing system, a level of cultural complexity unknown to the Olmecs.

Tres Zapotes and eventually Cerro de las Mesas were the largest Epi-Olmec centers though neither would reach the size and importance of the great Olmec cities before them nor El Tajín after them. Other Epi-Olmec sites of note include El Mesón, Lerdo de Tejada, La Mojarra, Bezuapan, and Chuniapan de Abajo.

Classic Veracruz culture (or Gulf Coast Classic culture) refers to a cultural area in the north and central areas of the present-day Mexican state of Veracruz, a culture that existed from roughly 100 to 1000 CE, or during the Classic era.

El Tajin was the major center of Classic Veracruz culture; other notable settlements include Higueras, Zapotal, Cerro de las Mesas, Nopiloa, and Remojadas, the latter two important ceramics centers. The culture spanned the Gulf Coast between the Pánuco River on the north and the Papaloapan River on the south.