Centrifuge in the context of "Gas centrifuge"

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⭐ Core Definition: Centrifuge

A centrifuge is a device that uses centrifugal force to subject a specimen to a specified constant force – for example, to separate various components of a fluid. This is achieved by spinning the fluid at high speed within a container, thereby separating fluids of different densities (e.g., cream from milk) or liquids from solids. It works by causing denser substances and particles to move outward in the radial direction. At the same time, objects that are less dense are displaced and moved to the centre. In a laboratory centrifuge that uses sample tubes, the radial acceleration causes denser particles to settle to the bottom of the tube, while low-density substances rise to the top. A centrifuge can be a very effective filter that separates contaminants from the main body of fluid.

Industrial scale centrifuges are commonly used in manufacturing and waste processing to sediment suspended solids, or to separate immiscible liquids. An example is the cream separator found in dairies. Very high speed centrifuges and ultracentrifuges able to provide very high accelerations can separate fine particles down to the nano-scale, and molecules of different masses. Large centrifuges are used to simulate high gravity or acceleration environments (for example, high-G training for test pilots). Medium-sized centrifuges are used in washing machines and at some swimming pools to draw water out of fabrics. Gas centrifuges are used for isotope separation, such as to enrich nuclear fuel for fissile isotopes.

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In this Dossier

Centrifuge in the context of Microgravity

Weightlessness is the complete or near-complete absence of the sensation of weight, i.e., zero apparent weight. It is also termed zero g-force, or zero-g (named after the g-force) or, incorrectly, zero gravity.

Weight is a measurement of the force on an object at rest in a relatively strong gravitational field (such as on the surface of the Earth). These weight-sensations originate from contact with supporting floors, seats, beds, scales, and the like. A sensation of weight is also produced, even when the gravitational field is zero, when contact forces act upon and overcome a body's inertia by mechanical, non-gravitational forces- such as in a centrifuge, a rotating space station, or within an accelerating vehicle.

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Centrifuge in the context of Precipitation (chemistry)

In an aqueous solution, precipitation is the "sedimentation of a solid material (a precipitate) from a liquid solution". The solid formed is called the precipitate. In case of an inorganic chemical reaction leading to precipitation, the chemical reagent causing the solid to form is called the precipitant.

The clear liquid remaining above the precipitated or the centrifuged solid phase is also called the supernate or supernatant.

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Centrifuge in the context of Centrifugal force

In Newtonian mechanics, a centrifugal force is a kind of fictitious force (or inertial force) that appears to act on all objects when viewed in a rotating frame of reference. It appears to be directed perpendicularly from the axis of rotation of the frame. The magnitude of the centrifugal force F on an object of mass m at the perpendicular distance ρ from the axis of a rotating frame of reference with angular velocity ω is .

The concept of centrifugal force simplifies the analysis of rotating devices by adopting a co-rotating frame of reference, such as in centrifuges, centrifugal pumps, centrifugal governors, and centrifugal clutches, and in centrifugal railways, planetary orbits and banked curves. The same centrifugal effect observed on rotating devices can be analyzed in an inertial reference frame as a consequence of inertia and the physical forces without invoking a centrifugal force.

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Centrifuge in the context of Centrifugation

Centrifugation is a mechanical process that involves the use of the centrifugal force to separate particles from a solution according to their size, shape, density, medium viscosity and rotor speed. The denser components of the mixture migrate away from the axis of the centrifuge, while the less dense components of the mixture migrate towards the axis. Chemists and biologists may increase the effective gravitational force of the test tube so that the precipitate (pellet) will travel quickly and fully to the bottom of the tube. The remaining liquid that lies above the precipitate is called a supernatant or supernate.

There is a correlation between the size and density of a particle and the rate that the particle separates from a heterogeneous mixture, when the only force applied is that of gravity. The larger the size and the larger the density of the particles, the faster they separate from the mixture. By applying a larger effective gravitational force to the mixture, like a centrifuge does, the separation of the particles is accelerated. This is ideal in industrial and lab settings because particles that would naturally separate over a long period of time can be separated in much less time.

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Centrifuge in the context of Settling

Settling is the process by which particulates move towards the bottom of a liquid and form a sediment. Particles that experience a force, either due to gravity or due to centrifugal motion will tend to move in a uniform manner in the direction exerted by that force. For gravity settling, this means that the particles will tend to fall to the bottom of the vessel, forming sludge or slurry at the vessel base.Settling is an important operation in many applications, such as mining, wastewater and drinking water treatment, biological science, space propellant reignition, and scooping.

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Centrifuge in the context of Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension. It makes up about 55% of the body's total blood volume. It is the intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (Na
, Ca
, Mg
, HCO3, Cl
, etc.), hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and oxygen. It plays a vital role in an intravascular osmotic effect that keeps electrolyte concentration balanced and protects the body from infection and other blood-related disorders.

Blood plasma can be separated from whole blood through blood fractionation, by adding an anticoagulant to a tube filled with blood, which is spun in a centrifuge until the blood cells fall to the bottom of the tube. The blood plasma is then poured or drawn off. For point-of-care testing applications, plasma can be extracted from whole blood via filtration or via agglutination to allow for rapid testing of specific biomarkers. Blood plasma has a density of approximately 1,025 kg/m (1.025 g/ml). Blood serum is blood plasma without clotting factors. Plasmapheresis is a medical therapy that involves blood plasma extraction, treatment, and reintegration.

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Centrifuge in the context of Heavy minerals

In geology, a heavy mineral is a mineral with a density that is greater than 2.9 g/cm, most commonly referring to dense components of siliciclastic sediments. A heavy mineral suite is the relative percentages of heavy minerals in a stone. Heavy mineral suites are used to help determine the provenance and history of sedimentary rocks.

As heavy minerals are a minor constituent of most sedimentary rock, they must be separated out to be studied. Heavy mineral separation generally uses a dense liquid in either a separatory funnel or centrifuge. Liquids used include bromoform, tetrabromoethane, tribromoethane, methylene iodide, and polytungstate liquids.

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