Caribbean Region of Colombia in the context of Cartagena de Indias

Cartagena (/ˌkɑːrtəˈhɛnə/ KAR-tə-HEN-ə), known since the colonial era as Cartagena de Indias (Spanish: [kaɾtaˈxena ðe ˈindjas] ), is a city and one of the major ports on the northern coast of Colombia in the Caribbean Coast Region, along the Caribbean Sea. Cartagena's past role as a link in the route to the West Indies provides it with important historical value for world exploration and preservation of heritage from the great commercial maritime routes. As a former Spanish colony, it was a key port for the export of Bolivian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. The city's strategic location between the Magdalena and Sinú rivers also gave it easy access to the interior of New Granada and made it a main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s.

Modern Cartagena is the capital of the Bolívar Department, and had a population of 876,885 according to the 2018 census, making it the second-largest city in the Caribbean region, after Barranquilla, and the fifth-largest city in Colombia. The metropolitan area of Cartagena is the sixth-largest urban area in the country, after metropolitan area of Bucaramanga. Economic activities include the maritime and petrochemical industries, as well as tourism.

Santa Marta (Spanish pronunciation: [ˌsanta ˈmaɾta]), officially the Distrito Turístico, Cultural e Histórico de Santa Marta (English: Historic, Cultural & Tourist District of Santa Marta), is a port city on the coast of the Caribbean Sea in northern Colombia. It is the capital of Magdalena Department and the fourth-largest urban city of the Caribbean Region of Colombia, after Barranquilla, Cartagena, and Soledad. Founded on July 29, 1525, by the Spanish conqueror Rodrigo de Bastidas, it was one of the first Spanish settlements in Colombia, its oldest surviving city, and second-oldest in South America. This city is situated on a bay by the same name and as such, it is a prime tourist destination in the Caribbean region.

Cesar Department (Spanish: Departamento del Cesar), or simply Cesar, (Spanish pronunciation: [seˈsaɾ]) is a department of Colombia located in the north of the country in the Caribbean region, bordering to the north with the Department of La Guajira, to the west with the Department of Magdalena and Department of Bolivar, to the south with Department of Santander, to the east with the Department of North Santander, and further to the east with the country of Venezuela (Zulia State). The department capital city is Valledupar.

The region was first inhabited by indigenous peoples known as Euparis in the Valley of Upar and Guatapuris in the Valley of the Cesar river, among these were the Orejones pertaining to the Toupeh, Acanayutos pertaining to the Motilon and Alcoholades pertaining to the Chimila. The first European to explore the area was Spanish Captain Peter Vadillo, but German Ambrose Alfinger savagely conquered the region in 1532.

Sucre (Spanish pronunciation: [ˈsukɾe]) is a department in the Caribbean Region of Colombia. The department ranks 27th by area, 10,670 km (4,120 sq mi) and it has a population of 904,863, ranking 20th of all the 32 departments of Colombia. Sucre is bordered by the Caribbean on the northwest; by Bolívar Department on the east and by Córdoba Department on the west.

Sucre was named in honor of the Independence hero Antonio José de Sucre who was quoted by the founders of this department in reference to Simón Bolívar's death as saying "They have killed my heart", expression said while cruising the territory of the present day Sucre Department.

The North Coast Cartel (Spanish: Cartel de la Costa or Cartel de la Costa Atlántica) was a drug cartel operating in northern Colombia between 1980 and 2010. It mostly controlled the illegal drug trade along the Colombian Caribbean coast, including shipments from other regions of Colombia, neighboring countries, and local production. Its operations center was the city of Barranquilla. It was also known as the Barranquilla Cartel (Spanish: Cartel de Barranquilla).