Byzantine Syria in the context of "Coele Syria (Roman province)"

The Muslim conquest of the Levant (Arabic: فَتْحُ الشَّام, romanized: Fatḥ al-šām; lit. 'Conquest of Syria'), or Arab conquest of Syria, was a 634–638 CE conquest of Byzantine Syria by the Rashidun Caliphate.

A part of the wider Arab–Byzantine wars, the Levant was brought under Arab Muslim rule and developed into the provincial region of Bilad al-Sham. Clashes between the Arabs and Byzantines on the southern Levantine borders of the Byzantine Empire had occurred during the lifetime of Muhammad, with the Battle of Muʿtah in 629 CE. However, the actual conquest did not begin until 634, two years after Muhammad's death. It was led by the first two Rashidun caliphs who succeeded Muhammad: Abu Bakr and Umar ibn al-Khattab. During this time, Khalid ibn al-Walid was the most important leader of the Rashidun army.

The conquest of the Maghreb by the Rashidun and Umayyad Caliphates commenced in 647 and concluded in 709, when the Byzantine Empire lost its last remaining strongholds to Caliph Al-Walid I. The North African campaigns were part of the century of rapid early Muslim conquests.

By 642 AD, under Caliph Umar, Arab Muslim forces had taken control of Mesopotamia (638 AD), Syria (641 AD), Egypt (642 AD), and had invaded Armenia (642 AD), all territories previously split between the warring Byzantine and Sasanian empires, and were concluding their conquest of Sasanian Persia with their defeat of the Persian army at the Battle of Nahāvand. It was at this point that Arab military expeditions into North African regions west of Egypt were first launched, continuing for years and furthering the spread of Islam.

The Byzantine Papacy was a period of Byzantine domination of the Roman Papacy from 537 to 752, when popes required the approval of the Byzantine Emperor for their episcopal consecration, and many popes were chosen from the apocrisiarii (liaisons from the pope to the emperor) or the inhabitants of Byzantine-ruled Greece, Syria, or Sicily. Justinian I reconquered the Italian peninsula in the Gothic War (535–554) and appointed the next three popes, a practice that would be continued by his successors and later be delegated to the Exarchate of Ravenna.

With the exception of Martin I, no pope during this period questioned the authority of the Byzantine monarch to confirm the election of the bishop of Rome before consecration could occur; however, theological conflicts were common between pope and emperor in the areas such as monothelitism and iconoclasm.

The Tanukh (Arabic: تنوخ, romanized: Tanūkh, sometimes referred to as the Tanukhids (التنوخيون, al-Tanūkhiyyūn), was an Arab tribal group whose history in the Arabian Peninsula and the Fertile Crescent spanned the 2nd century CE to the 17th century. The group began as a confederation of Arab tribes in eastern Arabia in the 2nd century and migrated to Mesopotamia during Parthian rule in the 3rd century. The confederation was led around this time by its king Jadhima, whose rule is attested by a Greek–Nabatean inscription and who plays an epic role in the traditional narratives of the pre-Islamic period. At least part of the Tanukh migrated to Byzantine Syria in the 4th century, where they served as the first Arab foederati (tribal confederates) of the empire. The Tanukh's premier place among the foederati was lost after its rebellion in the 380s, but it remained a zealous Orthodox Christian ally of the Byzantines until the Muslim conquest of Syria in the 630s.

Under early Muslim rule, the tribe largely retained its Christian faith and settlements around Qinnasrin and Aleppo. The Tanukh was an ally of the Syria-based Umayyad Caliphate and became part of the Umayyads' main tribal support base, the Quda'a confederation. The Tanukh's fortunes, like that of Syria in general, declined under the Iraq-based Abbasid Caliphate, which forced its tribesmen to convert to Islam in 780. As a result of attacks during the Fourth Muslim Civil War in the early 9th century, the Tanukh's area of settlement shifted to Ma'arrat al-Nu'man and the coastal mountains between Latakia and Homs, which by the 10th century were called 'Jabal Tanukh'.