Biostatistics in the context of "Ronald Fisher"

Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the determinants of health of a population and the threats it faces is the basis for public health. The public can be as small as a handful of people or as large as a village or an entire city; in the case of a pandemic it may encompass several continents. The concept of health takes into account physical, psychological, and social well-being, among other factors.

Public health is an interdisciplinary field. For example, epidemiology, biostatistics, social sciences and management of health services are all relevant. Other important sub-fields include environmental health, community health, behavioral health, health economics, public policy, mental health, health education, health politics, occupational safety, disability, oral health, gender issues in health, and sexual and reproductive health. Public health, together with primary care, secondary care, and tertiary care, is part of a country's overall healthcare system. Public health is implemented through the surveillance of cases and health indicators, and through the promotion of healthy behaviors. Common public health initiatives include promotion of hand-washing and breastfeeding, delivery of vaccinations, promoting ventilation and improved air quality both indoors and outdoors, suicide prevention, smoking cessation, obesity education, increasing healthcare accessibility and distribution of condoms to control the spread of sexually transmitted diseases.

A disease cluster is an unusually large aggregation of a relatively uncommon disease (medical condition) or event within a particular geographical location or period. Recognition of a cluster depends on its size being greater than would be expected by chance. Identification of a suspected disease cluster may initially depend on anecdotal evidence. Epidemiologists and biostatisticians then assess whether the suspected cluster corresponds to an actual increase of disease in the area. Typically, when clusters are recognized, they are reported to public health departments in the local area. If clusters are of sufficient size and importance, they may be re-evaluated as outbreaks.

John Snow's pioneering investigation of the 1854 cholera outbreak in Soho, London, is seen as a classic example of the study of such a cluster.

Sir Ronald Aylmer Fisher FRS (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. He has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, Fisher was the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin, as his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis. For his contributions to biology, Richard Dawkins declared Fisher to be the greatest of Darwin's successors. He is also considered one of the founding fathers of Neo-Darwinism. According to statistician Jeffrey T. Leek, Fisher is the most influential scientist of all time on the basis of the number of citations of his contributions.

From 1919, he worked at the Rothamsted Experimental Station for 14 years; there, he analyzed its immense body of data from crop experiments since the 1840s, and developed the analysis of variance (ANOVA). He established his reputation there in the following years as a biostatistician. Fisher also made fundamental contributions to multivariate statistics.