Biomedical research in the context of Medicinal

Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of creativity and skill), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic and applied, under the umbrella of medical science). For example, while stitching technique for sutures is an art learned through practice, knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science.

The polymerase chain reaction (PCR) is a laboratory method widely used to amplify copies of specific DNA sequences rapidly, to enable detailed study. PCR was invented in 1983 by American biochemist Kary Mullis at Cetus Corporation. Mullis and biochemist Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993.

PCR is fundamental to many of the procedures used in genetic testing, research, including analysis of ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications including biomedical research and forensic science.

A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based conclusion. For example, a systematic review of randomized controlled trials is a way of summarizing and implementing evidence-based medicine. Systematic reviews, sometimes along with meta-analyses, are generally considered the highest level of evidence in medical research.

While a systematic review may be applied in the biomedical or health care context, it may also be used where an assessment of a precisely defined subject can advance understanding in a field of research. A systematic review may examine clinical tests, public health interventions, environmental interventions, social interventions, adverse effects, qualitative evidence syntheses, methodological reviews, policy reviews, and economic evaluations.

32°54′04″N 117°14′31″W / 32.901192°N 117.241937°W / 32.901192; -117.241937

Sanford Burnham Prebys is an American nonprofit biomedical research institute located in La Jolla, California, conducting biomedical and translational research, including stem cell and drug discovery studies. It operates a National Cancer Institute-designated Cancer Center and conducts genomics research.

A biomedical scientist is a scientist trained in biology, particularly in the context of medical laboratory sciences or laboratory medicine. These scientists work to gain knowledge on the main principles of how the human body works and to find new ways to cure or treat disease by developing advanced diagnostic tools or new therapeutic strategies. The research of biomedical scientists is referred to as biomedical research.

Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of Johns Hopkins School of Medicine in Baltimore, Maryland. Founded in 1889, Johns Hopkins Hospital and its school of medicine are considered to be the founding institutions of modern American medicine and the birthplace of numerous famed medical traditions, including rounds, residents, and house staff. Several medical specialties were founded at the hospital, including neurosurgery by Harvey Cushing and Walter Dandy, cardiac surgery by Alfred Blalock and Vivien Thomas, and child psychiatry by Leo Kanner. Johns Hopkins Children's Center, which serves infants, children, teens, and young adults aged 0–21, is attached to the hospital.

Johns Hopkins Hospital is widely regarded as one of the world's greatest hospitals and medical institutions. For 21 consecutive years from 1991 to 2020, it was ranked as the best overall hospital in the United States by U.S. News & World Report. In its 2019–2020 edition, U.S. News & World Report ranked the hospital on 15 adult specialties and 10 children's specialties; the hospital came in 1st in Maryland and third nationally behind the Mayo Clinic in Rochester, Minnesota and Massachusetts General Hospital in Boston. In 2021, the hospital marked 32 consecutive years of placing in the top five hospitals in the nation.

Veterinary education is the tertiary education of veterinarians. To become a veterinarian, one must first complete a degree in veterinary medicine Doctor of Veterinary Medicine (DVM, V.M.D., BVS, BVSc, BVMS, BVM etc.).

In the United States and Canada, almost all veterinary medical degrees are first entry degrees, and require several years of previous study at the university level. Many veterinary schools outside North America use the title "Faculty of Veterinary Science" instead of "College of Veterinary Medicine" or "School of Veterinary Medicine", and some veterinary schools in China, Japan and South Korea (such as the DVM degree-awarding Department of Veterinary Science and Animal Husbandry at Guangxi University in China and the Department of Veterinary Medicine at Tokyo University of Agriculture and Technology use the term "Department".) Veterinary schools are distinct from departments of animal science offering a pre-veterinary curriculum, teaching the biomedical sciences (and awarding a Bachelor of Science degree or the equivalent), and providing graduate veterinary education in disciplines such as microbiology, virology, and molecular biology.

Disorders of consciousness are medical conditions that inhibit consciousness. Some define disorders of consciousness as any change from complete self-awareness to inhibited or absent self-awareness and arousal. This category generally includes minimally conscious state and persistent vegetative state, but sometimes also includes the less severe locked-in syndrome and more severe but rare chronic coma. Differential diagnosis of these disorders is an active area of biomedical research. Finally, brain death results in an irreversible disruption of consciousness. While other conditions may cause a moderate deterioration (e.g., dementia and delirium) or transient interruption (e.g., grand mal and petit mal seizures) of consciousness, they are not included in this category.

A physician-scientist (in North American English) or clinician-scientist (in British English and Australian English) is a physician who divides their professional time between direct clinical practice with patients and scientific research. Physician-scientists traditionally hold both a medical degree and a Doctor of Philosophy, also known as an MD-PhD or DO-PhD. Compared to other clinicians, physician-scientists invest significant time and professional effort in scientific research, with ratios of research to clinical time ranging from 50/50 to 80/20.

Physician-scientists are often employed by academic or research institutions where they drive innovation across a wide range of medical specialties and may also use their extensive training to focus their clinical practices on specialized patient populations, such as those with rare genetic diseases or cancers. Although they are a minority of both practicing physicians and active research scientists, physician-scientists are often cited as playing a critical role in translational medicine and clinical research by adapting biomedical research findings to health care applications. Over time, the term physician scientist has expanded to holders of other clinical degrees—such as nurses, dentists, and veterinarians—who are also included by the United States National Institutes of Health (NIH) in its studies of the physician-scientist workforce (PSW).