Biomedical gerontology in the context of "Rejuvenation (aging)"

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⭐ Core Definition: Biomedical gerontology

Life extension is the concept of extending the human lifespan, either through incremental improvements in medicine or through radical increases in maximum lifespan beyond its generally-settled biological limit of around 125 years. This field of study has been explored by numerous researchers and advocates, including "life extensionists", "immortalists", and "longevists" (those who aspire to achieve prolonged lifespans themselves). These researchers and advocates hypothesize that future advancements in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such through artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans through complete rejuvenation to a state of optimal health and youth (agerasia). The ethical implications of life extension are a subject of discourse among bioethicists.

The sale of purported anti-aging products, such as supplements and hormone replacement therapy, is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such hormone products has not been proven to be effective or safe. Similarly, a variety of apps make claims to assist in extending the life of their users, or predicting their lifespans.

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Biomedical gerontology in the context of Biogerontology

Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal Biogerontology in 2000. It involves interdisciplinary research on the causes, effects, and mechanisms of biological aging. Biogerontologist Leonard Hayflick has said that the natural average lifespan for a human is around 92 years and, if humans do not invent new approaches to treat aging, they will be stuck with this lifespan. James Vaupel has predicted that life expectancy in industrialized countries will reach 100 for children born after the year 2000. Many surveyed biogerontologists have predicted life expectancies of more than three centuries for people born after the year 2100. Other scientists, more controversially, suggest the possibility of unlimited lifespans for those currently living. For example, Aubrey de Grey offers the "tentative timeframe" that with adequate funding of research to develop interventions in aging such as strategies for engineered negligible senescence, "we have a 50/50 chance of developing technology within about 25 to 30 years from now that will, under reasonable assumptions about the rate of subsequent improvements in that technology, allow us to stop people from dying of aging at any age". The idea of this approach is to use presently available technology to extend lifespans of currently living humans long enough for future technological progress to resolve any remaining aging-related issues. This concept has been referred to as longevity escape velocity.

Biomedical gerontology, also known as experimental gerontology and life extension, is a sub-discipline of biogerontology endeavoring to slow, prevent, and even reverse aging in both humans and animals.

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