Josse Lieferinxe (fl. c. 1493–1503/08) was a South Netherlandish painter, formerly known by the pseudonym the Master of St. Sebastian.
Originating in the diocese of Cambrai in Hainaut, then part of the territories ruled by the Dukes of Burgundy, Josse Lieferinxe was documented as a "Picard" in the regions of Avignon and Marseille at the end of the fifteenth and in the early sixteenth centuries. He was first mentioned in Provence in 1493. Thus he figures among the painters of the Provençal school, whose most prominent members in an earlier generation had also been from the far north of the French-speaking world—Barthélemy d'Eyck and Enguerrand Quarton. In 1503 he married Michelle, a daughter of Jean Changenet, the most prominent painter of Avignon, in whose atelier Lieferinxe may have matured his style. He was last mentioned living in 1505, and in 1508 as deceased.