Barsine (Greek: Βαρσίνη; c. 363–309 BC) was the daughter of a Persian father, Artabazus, satrap of Hellespontine Phrygia, and a Greek Rhodian mother, the sister of mercenaries Mentor of Rhodes and Memnon of Rhodes. Barsine became the wife of her uncle Mentor, and after his death married her second uncle, Memnon.
In 334 BC, the year of Alexander's invasion of Asia, she and her children were sent by Memnon to the king Darius III as hostages for his fidelity; and in the ensuing year, when Damascus was betrayed to the Macedonians, she fell into the hands of Alexander, by whom it is said that she became the mother of Heracles.