Banu Hashim in the context of "Quraysh"

Muhammad (c. 570 – 8 June 632 CE) was an Arab religious, military and political leader and the founder of Islam. According to Islam, he was a prophet who was divinely inspired to preach and confirm the monotheistic teachings of Adam, Noah, Abraham, Moses, Jesus, and other prophets. He is believed by Muslims to be the Seal of the Prophets, and along with the Quran, his teachings and normative examples form the basis for Islamic religious belief.

According to the traditional account, Muhammad was born in Mecca to the aristocratic Banu Hashim clan of the Quraysh. He was the son of Abdullah ibn Abd al-Muttalib and Amina bint Wahb. His father, Abdullah, the son of tribal leader Abd al-Muttalib ibn Hashim, died around the time Muhammad was born. His mother Amina died when he was six, leaving Muhammad an orphan. He was raised under the care of his grandfather, Abd al-Muttalib, and paternal uncle, Abu Talib. In later years, he would periodically seclude himself in a mountain cave named Hira for several nights of prayer. When he was 40, in c. 610, Muhammad reported being visited by Gabriel in the cave and receiving his first revelation from God. In 613, Muhammad started preaching these revelations publicly, proclaiming that "God is One", that complete "submission" (Islām) to God (Allāh) is the right way of life (dīn), and that he was a prophet and messenger of God, similar to other prophets in Islam.

Arab Muslims (Arabic: ﺍﻟْمُسْلِمون ﺍﻟْﻌَﺮَﺏ, romanized: al-Muslimūn al-ʿArab) are the Arabs who adhere to Islam. They are the largest subdivision of the Arab people and the largest ethnic group among Muslims globally, followed by Bengalis and Punjabis. Likewise, they comprise the majority of the population of the Arab world. Currently, around 93% of Arabs are Muslims, while the rest are mainly Arab Christians, as well as Druze and Baháʼís.

Although Arabs account for the largest ethnicity among the world's adherents of Islam, they are a minority in the Muslim world in terms of sheer numbers. Muhammad, the founder of Islam, was an ethnic Arab belonging to the Banu Hashim of the Quraysh, and most of the early Muslims were also Arabs.

Hussein bin Ali al-Hashimi (Arabic: ٱلْحُسَيْن بِن عَلِي ٱلْهَاشِمِي, romanized: al-Ḥusayn bin 'Alī al-Hāshimī pronunciation; 1 May 1854 – 4 June 1931) was a Hejazi leader from the Banu Qatadah branch of the Banu Hashim clan who was the Sharif and Emir of Mecca from 1908 and, after proclaiming the Great Arab Revolt against the Ottoman Empire, King of the Hejaz, even if he refused this title, from 1916 to 1924. He proclaimed himself Caliph after the abolition of the Ottoman Caliphate in 1924 and stayed in power until 1925 when Hejaz was invaded by the Sultanate of Nejd. His Caliphate was opposed by the British and French empires, the Zionists and the Wahhabis alike. However, he received support from a large part of the Muslim population of that time and from Mehmed VI. He is usually considered as the father of modern pan-Arabism.

In 1908, in the aftermath of the Young Turk Revolution, Hussein was appointed Sharif of Mecca by the Ottoman sultan Abdul Hamid II. His relationship with the Ottoman government deteriorated after the Committee of Union and Progress took power, particularly because of their policies of Turkification and persecution of ethnic minorities, including Arabs. In 1916, with the promise of British support for Arab independence, although it is debated as to what extent the British were influential in his choice, he proclaimed the Arab Revolt against the Ottoman Empire, accusing the Committee of Union and Progress of violating tenets of Islam and limiting the power of the sultan-caliph. While his armies, led by his sons, were engaged in fighting the Ottoman and German troops in the Middle East, Hussein supported the Armenians during the Armenian genocide and saved up to 4,000 of them. In the aftermath of World War I, Hussein refused to ratify the Treaty of Versailles, in protest of the Balfour Declaration, a document supporting the Jewish settlers in Palestine, and the establishment of British and French mandates in Syria, Iraq, and Palestine. His sons Faisal and Abdullah were made rulers of Iraq and Transjordan respectively in 1921.

The Sharifian Caliphate (Arabic: الخلافة الشريفية, romanized: al-Khilāfat al-Sharīfiyya) was a Caliphate proclaimed by the Sharifian leaders of the Hejaz in 1924, replacing the Ottoman Caliphate, which was abolished by the Grand National Assembly of Turkey. Even though the Banu Hashim held the caliphate at various points in history, Hussein bin Ali, the Sharif of Mecca, was the first and last caliph of this lineage.

In the Arab world, it represented the culmination of a long struggle to reclaim the caliphate from Ottoman hands. The first Arab revolts challenging the validity of the Ottoman caliphate and demanding that an Arab Sayyid be chosen as caliph can be traced back to 1883 when Sheikh Hamat-al-Din seized Sanaa and called for the caliphate as a Sayyid.

Al-Marwani (Arabic: ُٱلْمَرْوَنِي, romanized: al-Marwānī) or Banu Marwan (Arabic: بَنِوُ مَرْوَانَ, lit. 'Sons of Marwan'), also referred to as the Marwanids (Arabic: ٱلْمَرْوَنِيُون, romanized: al-Marwāniyūn), is a prominent Arab clan belonging to the Banu Umayya branch of the Quraysh tribe. They are the descendants of Marwan ibn al-Hakam, fourth Umayyad caliph and paternal first cousin of the Rashidun caliph Uthman ibn Affan. Their roots lie in the holy city of Mecca in the Hejaz, the ancestral homeland of the Quraysh tribe, while their historical establishment was in Damascus, Syria. They are considered first cousins of the Banu Hashim, the clan of the Prophet Muhammad, since Umayya ibn Abd Shams ibn Abd Manaf was the paternal nephew of Hashim ibn Abd Manaf. They are also cousins of the Banu Shayba clan of Quraysh, the hereditary custodians of the Kaaba, through Marwan's maternal grandmother al-Sa'ba bint Abi Talha Abd Allah ibn Abd al-Uzza al-Abdariyya, the paternal aunt of Uthman ibn Talha ibn Abd Allah al-Abdari upon whom the Prophet Muhammad entrusted the guardianship of the keys of the Kaaba after the Conquest of Mecca.

The clan arrived in Damascus in the second half of the 7th century CE when Marwan I, the family's progenitor, moved from the Hejaz to Syria. His accession at the tribal conclave of Marj Rahit (684) marked the transfer of the caliphate within the Banu Umayya clan from the family of Abu Sufyan to his family. The family constitutes one of the two principal cadet branches of the Umayyad dynasty, the other being the Sufyanids, descended from Muʿawiya I ibn Abi Sufyan. At their height, the Marwanis represented the dominant branch of the Umayyad family, producing most of its ruling members and remaining the most numerous line of Umayyad descendants in later generations. The family supplied caliphs, princes, governors and commanders in the 7th–11th centuries and continued as a recognizable lineage in the central Islamic lands and in al-Andalus after 750.

The Abbasid dynasty, or Abbasids, (Arabic: بنو العباس, romanized: Banu al-ʿAbbās) was an Arab dynasty that ruled the third Islamic caliphate between 750 and 1258. They were from the Qurayshi Hashimid clan of Banu Abbas, descended from Abbas ibn Abd al-Muttalib. The Abbasid Caliphate is divided into three main periods: Early Abbasid era (750–861), Middle Abbasid era (861–936) and Later Abbasid era (936–1258). A cadet branch of the dynasty also ruled as ceremonial rulers for the Mamluk Sultanate (1261–1517) until their conquest by the Ottoman Empire.

When the Islamic prophet Muhammad initially spread Islam in his hometown, Mecca, he did not meet with any significant opposition from his tribesmen, the Quraysh. Rather, they were indifferent to his activities, as they did not appear to be particularly interested in devotional meetings. This was the case until Muhammad started attacking their beliefs, which caused tensions to arise. The Muslims then reportedly received persecution that lasted for twelve years beginning from the advent of Islam to the Hijrah.

Abu Talib, the chief leader of Muhammad's tribe, the Banu Hashim, supported his nephew Muhammad against other tribes. Muhammad's Tribe was boycotted in terms of marriage and business until they gave Muhammad to other tribes. The event forced Abu Talib to move the clans to a valley called Shi'b of Abu Talib. The boycott lasted three years and was ended when relatives of the clans intervened due to extreme poverty in the valley.