Astorre II Manfredi (8 December 1412 – 12 March 1468) was lord of Imola from 1439 and of Faenza from 1443.
He was born in Faenza, the son of Gian Galeazzo I Manfredi. Apart Faenza and Imola, he was Papal vicar at Fusignano and other lands in Romagna together with his brother Gian Galeazzo II. He also fought as captain for several local rulers.
The Manfredi were a noble family of northern Italy, who, with some interruptions, held the seigniory of the city of Faenza in Romagna from the beginning of the 14th century to the end of the 15th century. The family also held the seigniory of Imola for several decades at the same time.
The first mention of the Manfredi family in Faenza is dated 1050. The family members were patricians of the city and consuls. The first Manfredi lord of Faenza was Francesco I Manfredi, son of Alberghetto and the last was Astorre Manfredi IV.