Apollonius of Tyana in the context of "Classical Anatolia"

Neopythagoreanism (or neo-Pythagoreanism) was a school of Hellenistic and Ancient Roman philosophy which revived Pythagorean doctrines. Neopythagoreanism was influenced by middle Platonism and in turn influenced Neoplatonism. It originated in the 1st century BC and flourished during the 1st and 2nd centuries AD. The Encyclopædia Britannica Eleventh Edition describes Neopythagoreanism as "a link in the chain between the old and the new" within Hellenistic philosophy. Central to Neopythagorean thought was the concept of a soul and its inherent desire for a unio mystica with the divine. The word Neopythagoreanism is a modern (19th century) term, coined as a parallel of "Neoplatonism".

The therapeutae of Asclepius were a recognized and designated association in antiquity that included the physicians, their attendants and support staff, in the larger temples of Asclepius. These healing temples were known as Asclepeions. Examples of famous therapeutae of Asclepius prior to 300 BCE include many presocratic philosophers such as Parmenides and Empedocles according to ongoing scholarship. Asclepeion's between 300 BCE and 300 CE include Hippocrates, Apollonius of Tyana, Aelius Aristides and Galen.

The Greek word therapeutes θεραπευτής has the primary meaning of 'one who serves the gods, 'worshipper', or one who is or attendant to the gods. Therapeutae (plural) is Latin from the Greek plural Therapeutai (Θεραπευταί). The related adjective therapeutikos carry in later texts the meaning of attending to heal, or treating in a spiritual or medical sense. The Greek feminine plural Therapeutrides (Θεραπευτρίδες) is sometimes encountered for their female members. The term therapeutae may occur in relation to followers of Asclepius at Pergamon, and therapeutai may also occur in relation to worshippers of Sarapis in inscriptions, such as on Delos.

Gymnosophists (Ancient Greek: γυμνοσοφισταί, gymnosophistaí, i.e. "naked philosophers" or "naked wise men" (from Greek γυμνός gymnós "naked" and σοφία sophía "wisdom")) were ancient Indian philosophers who pursued asceticism to the point of regarding food and clothing as detrimental to purity of thought. They are mentioned several times in Ancient Greek literature.

They are mentioned in association with the Persian magi, the Chaldaeans of the Assyrians and Babylonians, the druids of the Celts, and the priests of Egypt. Some sources claim that famous figures such as Lycurgus, Pythagoras, and Democritus may have met them. They are mentioned by authors such as Philo, Lucian, Clement of Alexandria, Philostratus, and Heliodorus of Emesa. These reports are thought to have served as models to Cynics as well as Christian ascetics. Many authors have discussed the purported questions by Alexander the Great and answers by the Gymnosophists. There were also gymnosophists in Upper Egypt who were called Ethiopian Gymnosophists by Apollonius of Tyana. They were noted to have been vegetarian by several Greek authors.

Life of Apollonius of Tyana (Ancient Greek: Τὰ ἐς τὸν Τυανέα Ἀπολλώνιον), also known by its Latin title Vita Apollonii, is a text in eight books written in Ancient Greece by Philostratus (c. AD 170 – c. AD 245). It tells the story of Apollonius of Tyana (c. AD 15 – c. AD 100), a Pythagorean philosopher and teacher.

Damis (Greek: Δάμις) was a student and lifelong companion of Apollonius of Tyana, the famous Neopythagorean philosopher and teacher who lived in the early 1st up to the early 2nd century AD.