Antonio da Sangallo the Younger in the context of "Trajan's Market"

Michelangelo di Lodovico Buonarroti Simoni (6 March 1475 – 18 February 1564), known mononymously as Michelangelo, was an Italian sculptor, painter, architect, and poet of the High Renaissance. He was born in the Republic of Florence but was mostly active in Rome from his 30s onwards. His work was inspired by models from classical antiquity and had a lasting influence on Western art. Michelangelo's creative abilities and mastery in a range of artistic arenas define him as an archetypal Renaissance man, along with his rival and elder contemporary, Leonardo da Vinci. Given the sheer volume of surviving correspondence, sketches, and reminiscences, Michelangelo is one of the best-documented artists of the 16th century. He was lauded by contemporary biographers as the most accomplished artist of his era.

Michelangelo achieved fame early. Two of his best-known works, the Pietà and David, were sculpted before the age of 30. Although he did not consider himself a painter, Michelangelo created two of the most influential frescoes in the history of Western art: the scenes from Genesis on the ceiling of the Sistine Chapel in Rome, and The Last Judgment on its altar wall. His design of the Laurentian Library pioneered Mannerist architecture. At the age of 71, he succeeded Antonio da Sangallo the Younger as the architect of St. Peter's Basilica. Michelangelo transformed the plan so that the Western end was finished to his design, as was the dome, with some modification, after his death.

Palazzo Farnese ([paˈlattso farˈneːze, -eːse]) or Farnese Palace is one of the most important High Renaissance palaces in Rome. Owned by the Italian Republic, it was given to the French government in 1936 for a period of 99 years, and currently serves as the French embassy in Italy.

First designed in 1517 for the Farnese family, the building expanded in size and conception when Alessandro Farnese became Pope Paul III in 1534, to designs by Antonio da Sangallo the Younger. Its building history involved some of the most prominent Italian architects of the 16th century, including Michelangelo, Jacopo Barozzi da Vignola and Giacomo della Porta.

Caprarola is a town and comune in the province of Viterbo, in the Lazio region of central Italy. The village is situated in a range of volcanic hills known as the Cimini Mounts.

The town is home to the large Renaissance mansion or villa which dominates the surrounding country-side, Villa Farnese (or Villa Caprarola). Not to be confused with the Palazzo Farnese in Rome, it was initially built as a fortress, as the town and the surrounding area was a feud of the House of Farnese, by the cardinal Alessandro Farnese senio in 1530, according to a project of the architect Antonio da Sangallo the Younger. After only four years the project came to a halt when the cardinal was elected pope in 1534 under the name Paul III.

Baldassare Tommaso Peruzzi (7 March 1481 – 6 January 1536) was an Italian architect and painter, born in a small town near Siena (in Ancaiano, frazione of Sovicille) and died in Rome. He worked for many years with Bramante, Raphael, and later Sangallo during the erection of the new St. Peter's. He returned to his native Siena after the Sack of Rome (1527) where he was employed as architect to the Republic. For the Sienese he built new fortifications for the city and designed (though did not build) a remarkable dam on the Bruna River near Giuncarico. He seems to have moved back to Rome permanently by 1535. He died there the following year and was buried in the Rotunda of the Pantheon, near Raphael.

He was a painter of frescoes in the Cappella San Giovanni (Chapel of St John the Baptist) in the Duomo of Siena.

The Pozzo di San Patrizio (English: "Well of St. Patrick") is a historic well in Orvieto, Umbria, central Italy. The city is high on the flat summit of a large butte of volcanic tuff that was fortified with defensive walls. The well was built between 1527 and 1537 by the architect-engineer Antonio da Sangallo the Younger of Florence, at the behest of Pope Clement VII who had taken refuge at Orvieto during the sack of Rome in 1527 by the Holy Roman Emperor Charles V. The city proved to be an excellent refuge except that Clement feared that the natural water supply for Orvieto would be insufficient in the event of a protracted siege. The well was completed in 1537 during the papacy of Pope Paul III.

The name was inspired by medieval legends that St. Patrick's Purgatory in Ireland gave access down to Purgatory, indicating something very deep.