Antiochus of Ascalon in the context of "New Academy"

Middle Platonism is the modern name given to a revival and outgrowth of Platonic philosophy, lasting from about 90 BC – when Antiochus of Ascalon rejected the scepticism of the new Academy – until the development of neoplatonism under Plotinus in the 3rd century. Middle Platonism absorbed many doctrines from the rival Peripatetic and Stoic schools. The pre-eminent philosopher in this period, Plutarch (c. 45–120), defended the freedom of the will and the immortality of the soul. He sought to show that God, in creating the world, had transformed matter, as the receptacle of evil, into the divine soul of the world, where it continued to operate as the source of all evil. God is a transcendent being, who operates through divine intermediaries, which are the gods and daemons of popular religion. Numenius of Apamea (c. 160) combined Platonism with neopythagoreanism and other eastern philosophies, in a move which would prefigure the development of neoplatonism.

Academic skepticism was the philosophy of the skeptical period of the Academy dating from around 266 BCE, when Arcesilaus became scholarch, until around 90 BCE, when Antiochus of Ascalon rejected skepticism, although individual philosophers, such as Favorinus and his teacher Plutarch, continued to defend skepticism after this date. Unlike the existing school of skepticism, the Pyrrhonists, they maintained that knowledge of things is impossible. Ideas or notions are never true; nevertheless, there are degrees of plausibility, and hence degrees of belief, which allow one to act. The school was characterized by its attacks on the Stoics, particularly their dogma that convincing impressions led to true knowledge. The most important Academics were Arcesilaus, Carneades, and Philo of Larissa. The most extensive ancient source of information about Academic skepticism is Academica, written by the Academic skeptic philosopher Cicero.

De finibus bonorum et malorum ("On the ends of good and evil") is a Socratic dialogue by the Roman orator, politician, and Academic Skeptic philosopher Marcus Tullius Cicero. It consists of three dialogues, over five books, in which Cicero discusses the philosophical views of Epicureanism, Stoicism, and the Platonism of Antiochus of Ascalon (whose hybrid system mingled Stoicism with an "Old Academy" tradition of Platonism and Aristotelianism). The treatise is structured so that each philosophical system is described in its own book and then disputed in the following book (with exception of Antiochus' view which is both explained and disputed in book five). The book was developed in the summer of the year 45 BC, and was written over the course of about one and a half months. Together with the Tusculanae Quaestiones written shortly afterwards and the Academica, De finibus bonorum et malorum is one of the most extensive philosophical works of Cicero.

Cicero dedicated the book to Marcus Junius Brutus.