Christianity in the ante-Nicene period was the period in Christian history following the Apostolic Age (1st century AD) up to the First Council of Nicaea (325 AD). Although the use of the term Christian (Koine Greek: Χριστιανός) is attested in the Acts of the Apostles (80–90 AD), the earliest recorded use of the term Christianity (Koine Greek: Χριστιανισμός) is attested by the ante-Nicene Father and theologian Ignatius of Antioch (c. 107 AD).
While the Jewish–Christian community was centered in Jerusalem in the 1st century AD, Gentile Christianity spread widely in the 2nd century AD. One stream of Gentile Christianity (so-called "proto-Orthodox Christianity") that emerged in this period in the persons and theological positions of the Apostolic Fathers would eventually become the international Great Church. Proto-Orthodox Christianity placed importance on the sacrifice of Jesus on the cross as saving humanity, and described Jesus as the incarnated Son of God come to Earth. The 2nd and 3rd centuries AD saw a sharp separation between Jewish Christianity and Gentile Christianity, with the latter being derived from the teachings of the Apostle Paul. There was an explicit rejection of Second Temple Judaism and Jewish culture by the end of the 2nd century, with a growing body of anti-Jewish Christian literature. Many doctrinal variations in this era defy neat categorizations, as various forms of Christianity interacted in a complex fashion.