Anastasio Bustamante in the context of "Guadalupe Victoria"

The Centralist Republic of Mexico (Spanish: República Centralista de México), or in the anglophone scholarship, the Central Republic, officially the Mexican Republic (Spanish: República Mexicana), was a unitary political regime established in Mexico on 23 October 1835, under a new constitution known as the Siete Leyes (lit. 'seven laws') after conservatives repealed the federalist Constitution of 1824 and ended the First Mexican Republic. It would ultimately last until 1846, when the Constitution of 1824 was restored at the beginning of the Mexican–American War.

Two presidents would predominate throughout this era: Santa Anna and Anastasio Bustamante.

Vicente Ramón Guerrero Saldaña (Spanish: [biˈsente raˈmoŋ ɡeˈreɾo]; baptized 10 August 1782 – 14 February 1831) was a Mexican military officer from 1810–1821 and a statesman who became the nation's second president in 1829. He was one of the leading generals who fought against Spain during the Mexican War of Independence. According to historian Theodore G. Vincent, Vicente Guerrero lived alongside indigenous people in Tlaltelulco and had the ability to speak Spanish and the languages of the Indigenous.

During his presidency, he abolished slavery in Mexico. Guerrero was deposed in a rebellion by his vice-president, Anastasio Bustamante.

Bases Orgánicas (English: Organic Bases) was the name given to the constitution of Mexico which came into effect in 1843. It was the second and final constitution attempted during the Centralist Republic of Mexico, after the Siete Leyes.

National instability had resulted in a coup which overthrew the presidency of Anastasio Bustamante at the end of 1841. The coup plotters led by Santa Anna had proclaimed the need for a new constitution, and held elections for a new constitutional congress. The newly elected congress however was not to the government's liking and it was subsequently dissolved in a self-coup at the end of 1842. A new government appointed a Council (Junta) of Notables that produced a new constitution on 12 June 1843.