Amtrak Midwest is a brand name applied by Amtrak to its state-supported routes in the Midwest states of Illinois, Michigan, Wisconsin, Minnesota, and Missouri. As of May 2024, Amtrak Midwest consists of eleven named trains:
- Borealis
- Hiawatha
- Illinois Service: Lincoln Service, Illinois Zephyr and Carl Sandburg, and Illini and Saluki
- Michigan Services: Blue Water, Wolverine, and Pere Marquette
- Missouri River Runner
The routes generally form a hub-and-spoke network around Chicago Union Station, with all trains terminating there except for one Missouri River Runner round trip.