Amniotic membrane in the context of Trophoblast

Amphibians are ectothermic, anamniotic, four-limbed vertebrate animals that constitute the class Amphibia. In its broadest sense, it is a paraphyletic group encompassing all tetrapods, but excluding the amniotes (tetrapods with an amniotic membrane, such as modern reptiles, birds and mammals). All extant (living) amphibians belong to the monophyletic subclass Lissamphibia, with three living orders: Anura (frogs and toads), Urodela (salamanders), and Gymnophiona (caecilians). Evolved to be mostly semiaquatic, amphibians have adapted to inhabit a wide variety of habitats, with most species living in freshwater, wetland or terrestrial ecosystems (such as riparian woodland, fossorial and even arboreal habitats). Their life cycle typically starts out as aquatic larvae with gills known as tadpoles, but some species have developed behavioural adaptations to bypass this.

Young amphibians generally undergo metamorphosis from an aquatic larval form with gills to an air-breathing adult form with lungs. Amphibians use their skin as a secondary respiratory interface, and some small terrestrial salamanders and frogs even lack lungs and rely entirely on their skin. They are superficially similar to reptiles like lizards, but unlike reptiles and other amniotes, require access to water bodies to breed. With their complex reproductive needs and permeable skins, amphibians are often ecological indicators to habitat conditions; in recent decades there has been a dramatic decline in amphibian populations for many species around the globe.