Ambracian Gulf in the context of "Greek National Road 42"

Epirus (/ɪˈpaɪrəs/) is a geographical and historical region in southeastern Europe, now shared between Greece and Albania. Classical Epirus roughly lay between the Pindus Mountains in the east and the Ionian Sea in the west, and between the Acroceraunian Mountains in the north and the Ambracian Gulf in the south. It is currently divided between the region of Epirus in northwestern Greece and the counties of Gjirokastër and Vlorë in southern Albania. The largest city and seat of the Greek administrative region of Epirus is Ioannina.

A rugged and mountainous region, in classical antiquity Epirus was the north-west area of ancient Greece. It was inhabited by the Greek tribes of the Chaonians, Molossians, and Thesprotians. It was home to the sanctuary of Dodona, the oldest oracle in ancient Greece, and the second most prestigious after Delphi. Unified into a single state in 370 BC by the Aeacidae dynasty, Epirus achieved fame during the reign of Pyrrhus of Epirus who fought the Roman Republic in a series of campaigns. Epirus subsequently became part of the Roman Republic along with the rest of Greece in 146 BC, which was followed by the Roman Empire and Eastern Roman Empire.

Ambracia (/æmˈbreɪʃə/; Ancient Greek: Ἀμβρακία, occasionally Ἀμπρακία, Ampracia) was a city of ancient Greece on the site of modern Arta. It was founded by the Corinthians in 625 BC and was situated about 11 km (7 mi) from the Ambracian Gulf, on a bend of the navigable river Arachthos (or Aratthus), in the midst of a fertile wooded plain.

Vonitsa (Greek: Βόνιτσα) is a town in the northwestern part of Aetolia-Acarnania in Greece, seat of the municipality of Aktio-Vonitsa. The beach town is situated on the south coast of the Ambracian Gulf, and is dominated by a Venetian fortress on a hill. Vonitsa is 13 kilometres (8 miles) southeast of Preveza, 18 kilometres (11 miles) northeast of the city of Lefkada and 90 kilometres (56 miles) northwest of Agrinio. The Greek National Road 42 (Lefkada - Amfilochia) passes through Vonitsa.

Preveza (Greek: Πρέβεζα, pronounced [ˈpreveza]) is a city in the region of Epirus, northwestern Greece, located on the northern peninsula of the mouth of the Ambracian Gulf. It is the capital of the regional unit of Preveza, which is the southern part of the region of Epirus. The Aktio-Preveza Immersed Tunnel –the first, and so far only, undersea tunnel in Greece– was completed in 2002. The 1,570 m (5,150 ft) long immersed tunnel connects Preveza in the north, to Aktio of western Acarnania to the south. The ruins of the ancient city of Nicopolis lie 7 kilometres (4 miles) north of Preveza.

The Arachthos (Greek: Άραχθος) is a river in the eastern Epirus region of Greece. Its source is in the Pindus mountains, near the town Metsovo (Ioannina regional unit). The Arachthos is 110 km (68 mi) long and its drainage area is 2,209 km (853 sq mi). Its upper course is known as Metsovitikos. From its confluence with the Dipotamos near the village of Batza it is called Arachthos. It flows towards the south, passing between the Athamanika and the Xerovouni mountains. Here it reaches the Plaka Bridge, the largest one-arch stone bridge in Greece. It enters the large Pournari Reservoir, in the Arta regional unit, which is about 18 km² and prevents flooding of the city of Arta and also supplies water to most of Epirus. The town of Peta is situated near the dam. Arta, about 8 km downstream of the dam, is the largest town on the river. Arta's historic landmark is the stone Bridge of Arta over the Arachthos. The river continues through the lowlands south of Arta, and finally empties into the Ambracian Gulf near Kommeno, 16 km southeast of Arta.

Amfilochia (Greek: Αμφιλοχία) is a town and a municipality in the northwestern part of Aetolia-Acarnania in Greece, on the site of ancient Amfilochia. Under the Ottoman Empire, it was known as Karvasaras (Καρβασαράς; Kervansaray in Turkish, from caravanserai).

Amfilochia is situated by the Ambracian Gulf and features an amphitheatre. Amfilochia dates back to the ancient times and also features the ancient cities of Amphilochian Argos and Limnaia (or Limnaea).