Alexis Clairaut in the context of "Intermolecular"

Sir Isaac Newton (/ˈnjuːtən/ ; 4 January [O.S. 25 December] 1643 – 31 March [O.S. 20 March] 1727) was an English polymath active as a mathematician, physicist, astronomer, alchemist, theologian, author, and inventor. He was a key figure in the Scientific Revolution and the Enlightenment that followed. His book Philosophiæ Naturalis Principia Mathematica (Mathematical Principles of Natural Philosophy), first published in 1687, achieved the first great unification in physics and established classical mechanics. Newton also made seminal contributions to optics, and shares credit with German mathematician Gottfried Wilhelm Leibniz for formulating infinitesimal calculus, though he developed calculus years before Leibniz. Newton contributed to and refined the scientific method, and his work is considered the most influential in bringing forth modern science.

In the Principia, Newton formulated the laws of motion and universal gravitation that formed the dominant scientific viewpoint for centuries until it was superseded by the theory of relativity. He used his mathematical description of gravity to derive Kepler's laws of planetary motion, account for tides, the trajectories of comets, the precession of the equinoxes and other phenomena, eradicating doubt about the Solar System's heliocentricity. Newton solved the two-body problem and introduced the three-body problem. He demonstrated that the motion of objects on Earth and celestial bodies could be accounted for by the same principles. Newton's inference that the Earth is an oblate spheroid was later confirmed by the geodetic measurements of Alexis Clairaut, Charles Marie de La Condamine, and others, convincing most European scientists of the superiority of Newtonian mechanics over earlier systems. He was also the first to calculate the age of Earth by experiment, and described a precursor to the modern wind tunnel. Further, he was the first to provide a quantitative estimate of the solar mass.

Philosophiæ Naturalis Principia Mathematica (English: The Mathematical Principles of Natural Philosophy), often referred to as simply the Principia (/prɪnˈsɪpiə, prɪnˈkɪpiə/), is a book by Sir Isaac Newton that expounds Newton's laws of motion and his law of universal gravitation. The Principia is written in Latin and comprises three volumes, and was authorized, imprimatur, by Samuel Pepys, then-President of the Royal Society on 5 July 1686 and first published in 1687.

The Principia is considered one of the most important works in the history of science. The French mathematical physicist Alexis Clairaut assessed it in 1747: "The famous book of Mathematical Principles of Natural Philosophy marked the epoch of a great revolution in physics. The method followed by its illustrious author Sir Newton ... spread the light of mathematics on a science which up to then had remained in the darkness of conjectures and hypotheses." The French scientist Joseph-Louis Lagrange described it as "the greatest production of the human mind". French polymath Pierre-Simon Laplace stated that "The Principia is pre-eminent above any other production of human genius". Newton's work has also been called "the greatest scientific work in history", and "the supreme expression in human thought of the mind's ability to hold the universe fixed as an object of contemplation". Mathematician Eric Temple Bell wrote "It is no miracle then, when the power of Newton's mathematical genius is taken into account, the Principia is the unsurpassed masterpiece of both scientific coordination and the art of scientific prediction that it is."

An intermolecular force (IMF; also secondary force) is the force that mediates interaction between molecules, including the electromagnetic forces of attractionor repulsion which act between atoms and other types of neighbouring particles (e.g. atoms or ions). Intermolecular forces are weak relative to intramolecular forces – the forces which hold a molecule together. For example, the covalent bond, involving sharing electron pairs between atoms, is much stronger than the forces present between neighboring molecules. Both sets of forces are essential parts of force fields frequently used in molecular mechanics.

The first reference to the nature of microscopic forces is found in Alexis Clairaut's work Théorie de la figure de la Terre, published in Paris in 1743. Other scientists who have contributed to the investigation of microscopic forces include: Laplace, Gauss, Maxwell, Boltzmann and Pauling.