Alexander Farnese, Duke of Parma in the context of "Holy League (1571)"

The Spanish Armada (often known as Invincible Armada, or the Enterprise of England, Spanish: Grande y Felicísima Armada, lit. 'Great and Most Fortunate Navy') was a Spanish fleet that sailed from Lisbon in late May 1588, commanded by Alonso de Guzmán, Duke of Medina Sidonia, an aristocrat without previous naval experience appointed by Philip II of Spain. His orders were to sail up the English Channel, join with the army of Alexander Farnese, Duke of Parma in Flanders, and escort an invasion force that would land in England and overthrow Elizabeth I. Its purpose was to reinstate Catholicism in England, end English support for the Dutch Republic in the north and prevent attacks by English and Dutch privateers against Spanish interests in the Americas.

The Spanish were opposed by an English fleet based in Plymouth. Faster and more manoeuvrable than the larger Spanish galleons, its ships were able to attack the armada as it sailed up the Channel. Several subordinates advised Medina Sidonia first to enter Plymouth Sound and attack the English fleet before it could leave harbour and then to anchor in the Solent and occupy the Isle of Wight, but he refused to deviate from his instructions to join with Parma. Although the armada reached Calais largely intact, while awaiting communication from Parma, it was attacked at night by English fire ships and forced to scatter. The armada suffered further losses in the ensuing Battle of Gravelines and was in danger of running aground on the Dutch coast when the wind changed, allowing it to escape into the North Sea. Pursued by the English, the Spanish ships returned home via Scotland and Ireland. Up to 24 ships were wrecked along the way before the rest managed to get home. Among the factors contributing to the defeat and withdrawal of the armada were bad weather conditions and the better employment of naval guns and battle tactics by the English.

The House of Farnese (/fɑːrˈneɪzi, -zeɪ/, also US: /-eɪsi/, Italian: [farˈneːze, -eːse]) was an influential family in Renaissance Italy. The titles of Duke of Parma and Piacenza, Duke of Latera and Duke of Castro were held by various members of the family.

Its most important members included Pope Paul III, Alessandro Farnese (a cardinal), Alexander Farnese, Duke of Parma and Piacenza (a military commander and Governor of the Spanish Netherlands), and Elisabeth Farnese, who became Queen of Spain and whose legacy was brought to her Bourbon descendants.