Al-Lat in the context of "Abu Sufyan ibn Harb"

In pre-Islamic Arabia, the dominant religious practice was that of Arab polytheism, which was based on the veneration of various deities and spirits, such as the god Hubal and the goddesses al-Lāt, al-‘Uzzā, and Manāt. Worship was centred on local shrines and temples, most notably including the Kaaba in Mecca. Deities were venerated and invoked through pilgrimages, divination, and ritual sacrifice, among other traditions. Different theories have been proposed regarding the role of "Allah" (a word in Arabic that is now chiefly associated with God in Islam) in the Meccan religion. Many of the physical descriptions of the pre-Islamic gods and goddesses are traced to idols, especially near the Kaaba, which is said to have contained up to 360 of them.

Other religions—namely Christianity, Judaism, and Zoroastrianism—were also represented in the region. The influence of the Roman Empire and the Kingdom of Aksum enabled the nurturing of Christian communities in northwestern, northeastern, and southern Arabia. In the other areas of the Arabian Peninsula, Christianity did not have as much of a presence, though it did secure some converts, and with the exception of Nestorianism in the northeast and around the Persian Gulf, the dominant form of the religion was Miaphysitism. Since the beginning of the Roman era, Jewish migration into Arabia had become increasingly frequent, resulting in the establishment of a prominent Jewish diaspora community, which was supplemented by local converts. Over time, Judaism grew throughout southern Arabia and the northwestern Hejaz.

Sakhr ibn Harb ibn Umayya (Arabic: صَخْرِ ٱبْن حَرْب ٱبْن أُمَيَّةَ, romanized: Ṣakhr ibn Ḥarb ibn Umayya; c. 560—653), commonly known by his kunya Abu Sufyan (Arabic: أَبُو سُفْيَانُ, romanized: Abū Sufyān), was a prominent opponent-turned companion and father-in-law of the Islamic prophet Muhammad. He was the father of the first Umayyad caliph Mu'awiya I (r. 661–680) and namesake of the Sufyanid line of Umayyad caliphs which ruled from 661 to 684.

Abu Sufyan was a leader and merchant from the Quraysh tribe of Mecca. During his early career, he often led trade caravans to Syria. He had been among the main leaders of Meccan opposition to Muhammad, the prophet of Islam, commanding the Meccans at the battles of the Uhud and Trench in 625 and 627 CE. However, when Muhammad entered Mecca in 630, he was among the first to submit and was given a stake in the nascent Muslim state, playing a role at the Battle of Hunayn and the subsequent destruction of the polytheistic sanctuary of al-Lat in Ta'if. After Muhammad's death, he may have been appointed as the governor of Najran by Caliph Abu Bakr (r. 632–634) for an unspecified period. Abu Sufyan later played a supporting role in the Muslim army at the Battle of the Yarmuk against the Byzantines in Syria. His sons Yazid and later Mu'awiya were given command roles in that province and the latter went on to establish the Umayyad Caliphate in 661.

Al-ʻUzzá or al-ʻUzzā (Arabic: العزى, pronounced [al ˈʕuzzaː]) was one of the three chief goddesses of Arabian religion in pre-Islamic times and she was worshipped by the pre-Islamic Arabs along with Al-Lat and Manāt. A stone cube at Nakhla (near Mecca) was held sacred as part of her cult. She is mentioned in Qur'an 53:19 as being one of the goddesses whom people worshiped.

Al-ʻUzzā, like Hubal, was called upon for protection by the pre-Islamic Quraysh. "In 624 at the 'battle called Uhud', the war cry of the Qurayshites was, "O people of Uzzā, people of Hubal!". Al-‘Uzzá also later appears in Ibn Ishaq's account of the alleged Satanic Verses.

Manāt (Arabic: مناة, pronounced [maˈnaːh] (pausa) or [maˈnaːt], Old Arabic: [manaˈwat]; also transliterated as Manāh) was a pre-Islamic Arabian goddess worshipped in the Arabian Peninsula before the rise of Islam and the Islamic prophet Muhammad in the 6/7th century. She was among Mecca's three chief goddesses, alongside her sisters, Al-Lat and Al-‘Uzzá, and among them, she was the original and the oldest.