Reza Qoli Mirza Afshar (Persian: رضا قلی میرزا افشار; 1719–1747) was the eldest son of Nader Shah of Afsharid Iran. After his father's coronation in 1736, Reza Qoli, aged 17, became the Governor of the province of Khorasan. During his tenure, he subdued rebellious khans and marched up to Bukhara to put an end to the Khanate of Bukhara, his father's enemies. Before heading off to India, Nader Shah appointed Reza Qoli the regent of Iran. Reza Qoli ensured peace through harsh measures when collecting taxes and executed people for petty crimes. He had Tahmasp II and Abbas III, two pretenders to the throne, killed, which caused an uproar among the people. When Nader Shah returned from India, he dismissed Reza Qoli as regent, snubbing him for his actions during the regency.
Afterwards, Reza Qoli served as a commander in his father's army, but the relationship between the two had turned to bitterness. Reza Qoli, constantly humiliated by Nader, criticised his father, and Nader grew more distrusting of his son. Although he later regretted it, Nader blinded Reza Qoli after suspecting him to be behind an assassination attempt in 1742. Reza Qoli was confided in Kalat fortress until 1747, when he was executed by his cousin and the claimant to the throne, Adel Shah.